Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | PRAME | ||||||||||
| Synonyms | CT130 | MAPE | OIP-4 | OIP4 | ||||||||||
| Gene Description | PRAME, preferentially expressed antigen in melanoma, is a germinal tissue-specific gene that may inhibit retinoic acid signalling (PMID: 16179254) and regulate transcription via interaction with a Cullin2-based E3 ubiquitin ligase (PMID: 21822215). PRAME is expressed in hematological malignancies and various solid tumors (PMID: 20799951), and elevated Prame expression has been associated with poor clinical outcome in melanoma (PMID: 15833814), neuroblastoma (PMID: 15240516), serous ovarian adenocarcinoma (PMID: 18709641), and breast cancer (PMID: 18648365). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
