Gene Detail
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| Gene Symbol | GAB1 | ||||||||||
| Synonyms | DFNB26 | ||||||||||
| Gene Description | GAB1, GRB2-associated-binding protein 1, is an adaptor protein that mediates signal transduction from tyrosine kinase receptors, including Egfr, Met, and Src to regulate cell proliferation and migration (PMID: 22751113). Amplification, overexpression, and somatic mutations have been observed in Bcr-Abl-positive adult acute lymphoblastic leukemia (PMID: 17312329), medulloblastoma (PMID: 21267586), breast cancer (PMID: 16959974), and colorectal cancer (PMID: 16959974). | ||||||||||
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