Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol GAB1
Synonyms DFNB26
Gene Description GAB1, GRB2-associated-binding protein 1, is an adaptor protein that mediates signal transduction from tyrosine kinase receptors, including Egfr, Met, and Src to regulate cell proliferation and migration (PMID: 22751113). Amplification, overexpression, and somatic mutations have been observed in Bcr-Abl-positive adult acute lymphoblastic leukemia (PMID: 17312329), medulloblastoma (PMID: 21267586), breast cancer (PMID: 16959974), and colorectal cancer (PMID: 16959974).


Additional content available in CKB BOOST