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Gene Symbol SETBP1
Synonyms MRD29 | SEB
Gene Description SETBP1, SET binding protein 1, is part of a multiprotein epigenetic complex, which regulates target genes including MECOM (PMID: 29875417) and the tumor suppressor protein phosphatase type 2a (PP2A) (PMID: 11231286). Overexpression and gain of function mutations in Setbp1 have been linked to a variety of myeloproliferative diseases with worse clinical outcomes (PMID: 23892662, PMID: 28447248) and loss and gain of function mutations and have been reported in leukemia (PMID: 29875417, PMID: 28346496).
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