Gene Detail
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| Gene Symbol | MAGI3 | ||||||||||
| Synonyms | dJ730K3.2 | MAGI-3 | ||||||||||
| Gene Description | MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3, localizes to epithelial cell tight junctions to regulate AKT1 through PTEN (PMID: 10748157). A fusion of MAGI3 with AKT3 has been identified in breast cancer (PMID: 22722202) and altered polyadenylation of MAGI3 mRNA produces a potentially oncogenic isoform in breast cancer (PMID: 27205883). | ||||||||||
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