Gene Detail


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Gene Symbol GLI2
Synonyms CJS | HPE9 | PHS2 | THP1 | THP2
Gene Description GLI2, GLI family zinc finger 2, is a transcription factor acting in the Sonic Hedgehog signaling pathway of developmental regulation and is also induced by TGF-beta independently of hedgehog (PMID: 21862631). Crosstalk from hedgehog and TGF-beta may create a cycle that amplifies GLI2-dependent metastasis (PMID: 21862631) and a FHL2-GLI2 fusion has been reported in sclerosing stromal tumors of the ovary (PMID: 31896750).
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