Gene Detail


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Gene Symbol EML4
Synonyms C2orf2 | ELP120 | EMAP-4 | EMAPL4 | ROPP120
Gene Description EML4, EMAP like 4, plays a role in microtubule formation and stability (PMID: 16890222) and is required for cell proliferation and survival (PMID: 31366041). The fusion protein of EML4-ALK results in transformation activity and is present in a small percentage of patients with non-small cell lung cancer (PMID: 17625570, PMID: 23341890, PMID: 31366041, PMID: 31432686) and has also been reported in pulmonary atypical carcinoid (PMID: 31559892) and cholangiocarcinoma (PMID: 31711728).


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Variant Impact Protein Effect Variant Description Associated with drug Resistance