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Gene Symbol PCLO
Synonyms ACZ | PCH3
Gene Description PCLO, piccolo presynaptic cytomatrix protein, is a component of presynaptic active zones and a scaffold protein that potentially plays a role in trafficking of synaptic vesicles (PMID: 12654920, PMID: 10707984). Overexpression of Pclo has been associated with poor survival in esophageal squamous cell carcinoma (PMID: 28263981) and PCLO mutations and amplification have been observed in esophageal squamous cell carcinoma (PMID: 28263981).
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