Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | RSPO1 | ||||||||||
| Synonyms | CRISTIN3 | RSPO | ||||||||||
| Gene Description | RSPO1, R-spondin 1, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling and ovarian development (PMID: 27270435). RSPO1 amplification has been identified in ovarian cancer and loss of function mutations in squamous cell carcinoma (PMID: 27270435), and increased Rspo1 expression has been associated with increased survival in lung adenocarcinoma (PMID: 31579414). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
