Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol ANXA1
Synonyms ANX1 | LPC1
Gene Description ANXA1, annexin A1, is also known as lipocortin I and encodes a calcium-dependent phospholipid protein in the annexin family and is involved in multiple biological processes such as proliferation, differentiation, apoptosis (PMID: 24156336), the innate immune response, inflammation (PMID: 32006544), and inhibition function of Treg cells (PMID: 32300050). Decreased expression of ANXA1 has been observed in several tumor types such as prostate and esophageal, while increased expression has been reported in others cancers, including breast (PMID: 24156336), liver (PMID: 31807177), and pancreatic (PMID: 17215481).
Additional content available in CKB BOOST