Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol HFE
Synonyms HFE1 | HH | HLA-H | MVCD7 | TFQTL2
Gene Description HFE, homeostatic iron regulator, modulates iron uptake through an interaction with Tfr1 and plays a role in iron homeostasis (PMID: 26456104, PMID: 28474781) and as a potential regulator of T lymphocyte activation (PMID: 28474781). HFE mutations may be associated with increased risk of colorectal cancer (PMID: 2099304, PMID: 12529348, PMID: 23553028).
Additional content available in CKB BOOST