Gene Detail

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Gene Symbol FOXA1
Synonyms HNF3A | TCF3A
Gene Description FOXA1, forkhead box A1, is a transcription factor that de-compacts condensed chromatin to expose hormone receptor binding sites (PMID: 31243372) and plays a role in regulation of tissue-specific gene expression, gene expression in differentiated tissue, and androgen signalling (PMID: 22722839). Foxa1 expression has been associated with various tumor types (PMID: 24948874; PMID: 24596370; PMID: 24528009) and is often mutated in hormone-receptor-driven prostate, breast, bladder and salivary cancers (PMID: 31243372).


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