Gene Detail
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| Gene Symbol | GEN1 | ||||||||||
| Synonyms | Gen | ||||||||||
| Gene Description | GEN1, GEN1 Holliday junction 5' flap endonuclease, is a structure-specific endonuclease capable of processing Holliday junctions during double-stranded DNA repair events within mitosis and meiosis (PMID: 28327556, PMID: 30590761). Somatic truncating GEN1 variants have been identified in breast cancer, but do not contribute significantly to BRCA1/2-negative familial breast cancer susceptibility (PMID: 20512659). | ||||||||||
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