Gene Detail

Gene Symbol GEN1
Synonyms Gen
Gene Description GEN1, Flap endonuclease GEN homolog 1, is a structure-specific endonuclease capable of processing Holliday junctions during double-stranded DNA repair events within mitosis and meiosis (PMID: 28327556). Somatic truncating GEN1 variants have been identified in breast cancers, but do not contribute significantly to BRCA1/2-negative familial breast cancer susceptibility (PMID: 20512659).
Entrez Id 348654
Chromosome 2
Map Location 2p24.2
Canonical Transcript NM_182625


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