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Gene Symbol GEN1
Synonyms Gen
Gene Description GEN1, GEN1 Holliday junction 5' flap endonuclease, is a structure-specific endonuclease capable of processing Holliday junctions during double-stranded DNA repair events within mitosis and meiosis (PMID: 28327556, PMID: 30590761). Somatic truncating GEN1 variants have been identified in breast cancer, but do not contribute significantly to BRCA1/2-negative familial breast cancer susceptibility (PMID: 20512659).


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