Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||AAA | ABETA | ABPP | AD1 | alpha-sAPP | APPI | CTFgamma | CVAP | PN-II | PN2 | preA4|
|Gene Description||APP, amyloid beta precursor protein, is a transmembrane protein that is cleaved to form peptides with a variety of functions, including cell growth and cell adherence (PMID: 25491510, PMID: 30500566). An APP-NRG1 fusion has been identified in pancreatic ductal adenocarcinoma (PMID: 29802158) and App overexpression in breast cancer cell lines promotes cell proliferation (PMID: 25491510).|