Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | APP | ||||||||||
| Synonyms | AAA | ABETA | ABPP | AD1 | alpha-sAPP | APPI | CTFgamma | CVAP | PN-II | PN2 | preA4 | ||||||||||
| Gene Description | APP, amyloid beta precursor protein, is a transmembrane protein that is cleaved to form peptides with a variety of functions, including cell growth and cell adherence (PMID: 25491510, PMID: 30500566). An APP-NRG1 fusion has been identified in pancreatic ductal adenocarcinoma (PMID: 29802158) and App overexpression in breast cancer cell lines promotes cell proliferation (PMID: 25491510). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
