Gene Detail


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Gene Symbol APP
Synonyms AAA | ABETA | ABPP | AD1 | alpha-sAPP | APPI | CTFgamma | CVAP | PN-II | PN2 | preA4
Gene Description APP, amyloid beta precursor protein, is a transmembrane protein that is cleaved to form peptides with a variety of functions, including cell growth and cell adherence (PMID: 25491510, PMID: 30500566). An APP-NRG1 fusion has been identified in pancreatic ductal adenocarcinoma (PMID: 29802158) and App overexpression in breast cancer cell lines promotes cell proliferation (PMID: 25491510).
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