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Gene Symbol INPP4A
Synonyms INPP4 | TVAS1
Gene Description INPP4A, inositol polyphosphate-4-phosphatase type I A, encodes a lipid phosphatase that dephosphorylates phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2) PIP2 into phosphatidylinositol-3,4,5-trisphosphate (PIP3), potentially resulting in PI3K pathway signaling (PMID: 26022180). Decreased expression of INPP4A has been identified in several tumor types, including breast, prostate, and ovarian cancer, melanoma, and leukemia (PMID: 26022180).
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