Gene Detail

Gene Symbol LAG3
Synonyms CD223
Gene Description LAG3, lymphocyte activation gene 3 protein, is expressed on activated T-cells and NK cells and binds MHC class II molecules to inhibit the immune response (PMID: 28258692). LAG3 inhibition in cancer therapy may relieve suppression of the anti-tumor immune response (PMID: 29900067, PMID: 29439955).
Entrez Id 3902
Chromosome 12
Map Location 12p13.31
Canonical Transcript NM_002286

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