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Gene Symbol SMAD4
Synonyms DPC4 | JIP | MADH4 | MYHRS
Gene Description SMAD4, mothers against decapentaplegic homolog 4, is a tumor suppressor (PMID: 30562755) that translocates to the nucleus upon TGF-beta signaling to form a protein complex that regulates gene transcription and cell growth (PMID: 28452926). SMAD4 germline mutations are associated with juvenile polyposis syndrome (PMID: 18559331) and Smad4 loss of function or inactivation is common in prostate, colorectal (PMID: 29720405), and pancreatic cancer, which may be a marker for poor prognosis (PMID: 28067794).
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