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Gene Symbol MC1R
Synonyms CMM5 | MSH-R | SHEP2
Gene Description MC1R, melanocortin 1 receptor, is a G protein-coupled receptor that binds to alpha-MSH and ACTH and regulates pigment production, and also plays a role in response to UV radiation and DNA repair (PMID: 24807163, PMID: 29622793, PMID: 34362555). MC1R variants have been associated with an increased risk for melanoma (PMID: 11500805, PMID: 20876876, PMID: 32898390).
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