Gene Detail

Gene Symbol MDM2
Synonyms ACTFS | hdm2 | HDMX
Gene Description MDM2, MDM2 proto-oncogene, is an E3 ubiquitin protein ligase that mediates Tp53 degradation and therefore, regulates apoptosis and cell-cycle (PMID: 27993876). Dysregulation of MDM2 has been identified in several cancer types (PMID: 23303139) and amplification is common in liposarcoma (PMID: 30237864).
Entrez Id 4193
Chromosome 12
Map Location 12q15
Canonical Transcript XM_005268872


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