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Gene Symbol MDM4
Synonyms HDMX | MDMX | MRP1
Gene Description MDM4, MDM4, p53 regulator, inhibits Tp53 activity through interaction with the transcriptional activation domain of Tp53, and regulates Tp53 degradation together with Mdm2 (PMID: 23303139). MDM4 amplification leads to overexpression of Mdm4 in many cancers, including sarcoma, retinoblastoma, breast, lung, and colon cancers, as well as melanoma (PMID: 27371671).

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