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|Synonyms||MAPKKK1 | MEKK | MEKK 1 | MEKK1 | SRXY6|
|Gene Description||MAP3K1, mitogen-activated protein kinase kinase kinase 1, is a E3 ubiquitin protein ligase and serine/threonine kinase that regulates JNK and ERK signaling and the full length Map3k1 protein functions in cell migration and cell survival, while the caspase-cleaved C-terminal Map3k1 fragment acts to promote apoptosis (PMID: 24386504). MAP3K1 mutations have been identified in breast cancer (PMID: 31620934, PMID: 31552290, PMID: 29765551).|