Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol MAP3K1
Synonyms MAPKKK1 | MEKK | MEKK 1 | MEKK1 | SRXY6
Gene Description MAP3K1, mitogen-activated protein kinase kinase kinase 1, is a E3 ubiquitin protein ligase and serine/threonine kinase that regulates JNK and ERK signaling and the full length Map3k1 protein functions in cell migration and cell survival, while the caspase-cleaved C-terminal Map3k1 fragment acts to promote apoptosis (PMID: 24386504). MAP3K1 mutations have been identified in breast cancer (PMID: 31620934, PMID: 31552290, PMID: 29765551).
Additional content available in CKB BOOST