Gene Detail

Gene Symbol MAP3K1
Synonyms MAPKKK1 | MEKK | MEKK 1 | MEKK1 | SRXY6
Gene Description MAP3K1, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase, is a serine/threonine kinase that regulates JNK and ERK signaling. Full length Map3k1 protein functions in cell migration and cell survival, while the caspase-cleaved C-terminal Map3k1 fragment acts to promote apoptosis (PMID: 24386504).
Entrez Id 4214
Chromosome 5
Map Location 5q11.2
Canonical Transcript NM_005921


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