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|Synonyms||ASK1 | MAPKKK5 | MEKK5|
|Gene Description||MAP3K5, mitogen-activated protein kinase kinase kinase 5, plays a key role in the immune and stress response, and regulates apoptosis and inflammation through the activation of intracellular signaling pathways (PMID: 24008424, PMID: 23031789, PMID: 17883330, PMID: 10734135). MAP3K5 mutations and amplifications have been demonstrated in melanoma (PMID 24008424) and malignant fibrous histiocytomas (PMID: 15034865).|