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Gene Symbol MAP3K10
Synonyms MEKK10 | MLK2 | MST
Gene Description MAP3K10, mitogen-activated protein kinase kinase kinase 10, is a MAP kinase kinase kinase (MAP3K) that plays a role in of TGF-beta induced MAPK activation, regulation of JNK and Shh pathway signaling, and cell proliferation and apoptosis (PMID: 23760366, PMID: 9182538, PMID: 23178452, PMID: 11278395). MAP3K10 overexpression has been demonstrated in pancreatic cancer (PMID: 23178452).
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