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Gene Symbol H3-5
Synonyms H3.3C | H3.5 | H3F3C
Gene Description H3-5, H3.5 histone, is a testis-specific histone H3 variant that potentially plays a role in nucleosome stability in germ cells and is enriched near exon regions (PMID: 21274551, PMID: 26779285). Mutations in H3-5 have been observed in various advanced solid tumors, including uterine corpus endometrial carcinoma and lung squamous cell carcinoma (PMID: 24132290).
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