Gene Detail

Gene Symbol MSH2
Synonyms COCA1 | FCC1 | hMSH2 | HNPCC | HNPCC1 | LCFS2
Gene Description MSH2, DNA mismatch repair protein Msh2, is a tumor suppressor (PMID: 30562755) that functions as part of the DNA mismatch repair system (PMID: 9024626, PMID: 18157157) and is associated with microsatellite instability (MSI) (PMID: 30121009). Mutations in MSH2 are associated with susceptibility to colon cancer and endometrial cancer (PMID: 23255516), and germline MSH2 mutations are associated with Lynch (Hereditary Nonpolyposis Colorectal Cancer) syndrome (HNPCC1) (PMID: 15528792).
Entrez Id 4436
Chromosome 2
Map Location 2p21-p16.3
Canonical Transcript NM_000251

Additional content available in CKB BOOST