Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||BDMF | c86fus | DMSFH | DMSMFH | HEL-249 | LGMBF | MSAP|
|Gene Description||MTAP, methylthioadenosine phosphorylase, encodes an enzyme that plays a role in the methionine salvage pathway via catalyzing methylthioadenosine (MTA), a product of polyamine biosynthesis, and results in salvaging adenine and methionine (PMID: 26751376, PMID: 24324622). Loss of MTAP frequently occurs in a variety of tumors, including glioma (PMID: 32093414) lung cancer (PMID: 31965001), and malignant pleural mesothelioma (PMID: 31231127), which may result in an accumulation of MTA, leading to deregulation of cellular pathways (PMID: 27068473, PMID: 26819315).|