Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol MUTYH
Synonyms MYH
Gene Description MUTYH, mutY DNA glycosylase, encodes for an enzyme that is part of the base excision pathway, which is responsible for excising an adenine that was inserted into the DNA to pair with the oxidation base lesion, 8-Oxoguanine (PMID: 21235684). Germline MUTYH mutations have been linked to an increased risk for colorectal cancer development (PMID: 29147111, PMID: 31724937), and have been associated with an elevated risk for breast cancer (PMID: 21952991).
Additional content available in CKB BOOST