Gene Detail

Gene Symbol NF1
Synonyms NFNS | VRNF | WSS
Gene Description NF1, neurofibromin, is a tumor suppressor (PMID: 30562755), which activates Ras GTPase activity leading to increased cell proliferation and malignant transformation (PMID: 19380279). NF1 germline mutations are common in neurofibromatosis type I (PMID: 30562755) and somatic mutations have been identified in a variety of human cancers (PMID: 28637487).
Entrez Id 4763
Chromosome 17
Map Location 17q11.2
Canonical Transcript NM_001042492

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