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|Synonyms||NFNS | VRNF | WSS|
|Gene Description||NF1, neurofibromin, is a tumor suppressor (PMID: 30562755), which activates Ras GTPase activity leading to increased cell proliferation and malignant transformation (PMID: 19380279). NF1 germline mutations are common in neurofibromatosis type I (PMID: 30562755) and somatic mutations have been identified in a variety of human cancers (PMID: 28637487).|