Gene Detail
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| Gene Symbol | NF1 | ||||||||||
| Synonyms | NFNS | VRNF | WSS | ||||||||||
| Gene Description | NF1, neurofibromin, is a tumor suppressor (PMID: 30562755) which functions as a Ras GTPase-activating protein to regulate cell proliferation and prevent malignant transformation (PMID: 19380279, PMID: 35066574). NF1 germline mutations are common in neurofibromatosis type I (PMID: 30562755) and somatic mutations have been identified in a variety of human cancers (PMID: 28637487). | ||||||||||
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