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Gene Symbol NOTCH1
Synonyms AOS5 | AOVD1 | hN1 | TAN1
Gene Description NOTCH1, notch receptor 1, is one of four Notch transmembrane receptors, that bind Delta or Jagged ligands (PMID: 30289388), and plays a role in cell fate determination, growth, survival (PMID: 25388163) and chemoresistance (PMID: 29998084). Activating Notch1 mutations are common in T-cell lymphoblastic leukemia/lymphoma (PMID: 22006338, PMID: 30103821), chronic lymphocytic leukemia (PMID: 29998084) and amplification and/or overexpression has been observed in bladder (PMID: 29643502), colorectal (PMID: 30136202, PMID: 30043645, PMID: 32211044), and gastric cancers (PMID: 30043645).
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