Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol NOTCH4
Synonyms INT3
Gene Description NOTCH4, notch receptor 4, is one of four Notch transmembrane receptors, that bind Delta or Jagged ligands (PMID: 30289388), and plays a role in cell fate regulation, proliferation, and survival (PMID: 24403446). NOTCH4 overexpression in TNBC plays a role in proliferation and invasiveness (PMID: 24403446, PMID: 29805613), has been observed in tamoxifen-resistant breast cancer (PMID: 28108315) and oral squamous cell carcinoma (PMID: 27197026), and may be prognostic for progression in colorectal cancer (PMID: 30026833, PMID: 29693251).
Additional content available in CKB BOOST