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Gene Symbol NPM1
Synonyms B23 | NPM
Gene Description NPM1, nucleophosmin, is a phosphoprotein that shuttles between the nucleus and cytoplasm, and is involved in several cellular processes including ribosomal processing and export, chromatin remodeling, DNA replication and repair, and cell cycle control (PMID: 29157973, PMID: 23436734). NPM1 is frequently mutated in acute myeloid leukemia (PMID: 29157973, PMID: 23436734, PMID: 30122998, PMID: 29785446, PMID: 32203582, PMID: 32609823) and overexpression is implicated with poor prognosis in hematological and solid tumors (PMID: 32071709).

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Molecular Profile Protein Effect Treatment Approaches
NPM1 A53S unknown
NPM1 act mut gain of function
NPM1 - ALK ALK amp NPM1 amp
NPM1 amp no effect
NPM1 D55N unknown
NPM1 E185K unknown
NPM1 E226* unknown
NPM1 E245Q unknown
NPM1 exon12 unknown
NPM1 fusion unknown
NPM1 G147D unknown
NPM1 I138V unknown
NPM1 inact mut loss of function
NPM1 K141R unknown
NPM1 K257E unknown
NPM1 K263R loss of function
NPM1 K273N unknown
NPM1 L136F unknown
NPM1 L287fs unknown
NPM1 L294F unknown
NPM1 M251fs unknown
NPM1 mutant unknown
FLT3 wild-type NPM1 mut
FLT3 exon 14 ins NPM1 mut
DNMT3A mut FLT3 mut NPM1 mut
DNMT3A mut FLT3 exon 14 ins NPM1 mut
DNMT3A wild-type FLT3 mut NPM1 mut
DNMT3A mut NPM1 mut
NPM1 N203H unknown
NPM1 N38D unknown
NPM1 - ALK ALK I1171T
NPM1 - ALK gain of function ALK Inhibitor
NPM1 - ALK ALK L1196M Brigatinib Ceritinib
NPM1 - ALK ALK F1174V Brigatinib Ceritinib Crizotinib
NPM1 - ALK ALK L1198F Crizotinib
NPM1 - ALK ALK L1122V
NPM1 - ALK ALK L1122V ALK L1196M
NPM1 - ALK ALK P1139S Alectinib ASP3026 Brigatinib Crizotinib
NPM1 - ALK ALK S1206C
NPM1 - ALK ALK F1174V ALK L1198F Crizotinib
NPM1 - ALK ALK L1196M ALK D1203N ASP3026
NPM1 - ALK ALK I1171S AZD3463 Brigatinib
NPM1 - ALK ALK T1151M
NPM1 - ALK ALK F1174L Brigatinib
NPM1 - ALK ALK R1192P Brigatinib
NPM1 - ALK ALK G1269A ASP3026 AZD3463 Brigatinib
NPM1 - ALK ALK I1171N
NPM1 - ALK ALK C1156Y
NPM1 - ALK ALK F1174I Alectinib Brigatinib Ceritinib Crizotinib Lorlatinib
NPM1 - ALK ALK C1156F Crizotinib
NPM1 - ALK ALK E1210K Crizotinib
NPM1 - ALK ALK G1128S Brigatinib
NPM1 - ALK ALK C1156F ALK D1203N
NPM1 - ALK ALK N1178H Alectinib Crizotinib
NPM1 - ALK ALK L1196Q ASP3026
NPM1 - ALK ALK L1152R
NPM1 - ALK ALK G1202R
NPM1 - ALK ALK S1206Y
NPM1 - TYK2 gain of function
NPM1 over exp no effect
NPM1 P216S unknown
NPM1 S106L unknown
NPM1 S207* unknown
NPM1 V156fs loss of function - predicted
NPM1 V99A unknown
NPM1 W288Cfs*12 loss of function - predicted
NPM1 W288fs loss of function - predicted
DNMT3A R882H FLT3 Y599_D600insSTDNEYFYVDFREYEY NPM1 W288fs
NPM1 W288Lfs*12 loss of function - predicted
NPM1 wild-type no effect
FLT3 exon 14 ins NPM1 wild-type
FLT3 wild-type NPM1 wild-type