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Gene Symbol NTRK3
Synonyms gp145(trkC) | GP145-TrkC | TRKC
Gene Description NTRK3, neurotrophic receptor tyrosine kinase 3, is a membrane receptor tyrosine kinase that binds neurotrophins, initiating signaling cascades that lead to cell growth and differentiation (PMID: 23396845). NTRK3 has been described as a dependence receptor that induces apoptosis when ligand-free and so may be a tumor suppressor or oncogene, depending on context (PMID: 23396845), and ETV6-NTRK3 fusions are commonly observed in secretory breast carcinomas, spindle cell tumors of the kidney (PMID: 31075511), and other secretory carcinomas (PMID: 31423558, PMID: 31273600) and spindle cell tumors (PMID: 31112350).


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