Gene Detail

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Gene Symbol DDR2
Synonyms MIG20a | NTRKR3 | TKT | TYRO10 | WRCN
Gene Description DDR2, discoidin domain receptor tyrosine kinase 2, is a tyrosine kinase receptor activated by collagen, promoting cell migration, proliferation, and survival (PMID: 22328973, PMID: 27398168). Altered expression and mutations of DDR2 have been identified in a variety of solid tumors, including ovarian (PMID: 27398168), lung (PMID: 28161936), gastric (PMID: 27350126), and HNSCC (PMID: 27434411).

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
act mut unknown gain of function DDR2 act mut indicates that this variant results in a gain of function in the Ddr2 protein. However, the specific amino acid change has not been identified.
inact mut unknown loss of function DDR2 inact mut indicates that this variant results in a loss of function of the Ddr2 protein. However, the specific amino acid change has not been identified.
mutant unknown unknown DDR2 mutant indicates an unspecified mutation in the DDR2 gene.
R489fs frameshift loss of function - predicted DDR2 R489fs results in a change in the amino acid sequence of the Ddr2 protein beginning at aa 489 of 855, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), R489fs is predicted to result in a loss of Ddr2 protein function.