Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol OGG1
Synonyms HMMH | HOGG1 | MUTM | OGH1
Gene Description OGG1, 8-oxoguanine DNA glycosylase, plays a role in the repair and excision of oxidatively damaged DNA bases, specifically the excision of 8-oxoguanine, via the base excision repair pathway (PMID: 17116430, PMID: 18166975, PMID: 22048164) and in the repair of mitochondrial DNA through association with Sirt3 (PMID: 23868064, PMID: 11454679). OGG1 mutations have been identified in laryngeal cancer (PMID: 22829015), clear cell carcinoma of the kidney (PMID: 10987279), and decreased expression of OGG1 has been identified in head and neck squamous cell carcinoma (PMID: 24622884, PMID: 22081374).


Additional content available in CKB BOOST