Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||HMMH | HOGG1 | MUTM | OGH1|
|Gene Description||OGG1, 8-oxoguanine DNA glycosylase, plays a role in the repair and excision of oxidatively damaged DNA bases, specifically the excision of 8-oxoguanine, via the base excision repair pathway (PMID: 17116430, PMID: 18166975, PMID: 22048164) and in the repair of mitochondrial DNA through association with Sirt3 (PMID: 23868064, PMID: 11454679). OGG1 mutations have been identified in laryngeal cancer (PMID: 22829015), clear cell carcinoma of the kidney (PMID: 10987279), and decreased expression of OGG1 has been identified in head and neck squamous cell carcinoma (PMID: 24622884, PMID: 22081374).|