Gene Detail

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Gene Symbol PRDX1
Synonyms MSP23 | NKEF-A | NKEFA | PAG | PAGA | PAGB | PRX1 | PRXI | TDPX2
Gene Description PRDX1, peroxiredoxin 1, encodes a peroxidase, an antioxidant enzyme, that is induced by oxidative stress and acts as a chaperone to prevent damage (PMID: 27388124, PMID: 12891360), plays a role in re-dox signaling (PMID: 23334342), and has been shown to potentially act as an anti-inflammatory by interacting with APE1 and preventing activation of IL-8 (PMID: 27388124). Overexpression of PRDX1 has been associated with several tumor types including liver cancer (PMID: 26478675), esophagus squamous cell carcinoma (PMID: 24009050), squamous cell lung carcinoma (PMID: 17192052), and prostate cancer (PMID: 21343392).
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