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Gene Symbol PCM1
Synonyms PTC4 | RET/PCM-1
Gene Description PCM1, pericentriolar material 1, is a centriolar satellite protein, which recruits microtubule and dynactin-dependent proteins for appropriate microtubule organization (PMID: 12403812). A PCM1-RET fusion has been identified in papillary thyroid carcinoma (PMID: 10980597), PCM1 fusions with other genes have been observed in hematological cancers (PMID: 29797824, PMID: 26522767, PMID: 31085913, PMID: 29169164), and both overexpression and amplification of PCM1 have been linked to myeloid leukemias (PMID: 10980597, PMID: 23431203).
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