Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol DTL
Synonyms CDT2 | DCAF2 | L2DTL | RAMP
Gene Description DTL, denticleless E3 ubiquitin protein ligase homolog, encodes for a protein that plays a significant role in cell cycle control, including preventing additional cell replication via CDT1 regulation (PMID: 17085480) and degrades PDCD4 through the ubiquitin-proteasomal pathway (PMID: 31409387). DTL amplification and/or overexpression has been found to be associated with several cancer types including gastric, hepatocellular carcinoma, breast, and Ewing sarcoma (PMID: 26472028), and is associated with decreased survival in breast and lung cancer (PMID: 31409387).


Additional content available in CKB BOOST