Gene Detail
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| Gene Symbol | PDGFB | ||||||||||
| Synonyms | c-sis | IBGC5 | PDGF-2 | PDGF2 | SIS | SSV | ||||||||||
| Gene Description | PDGFB, platelet derived growth factor subunit B, is a growth factor that signals through PDGFRs and plays a role in regulation of development, cell proliferation, cell migration (PMID: 18483217), and angiogenesis (PMID: 32235327). Overexpression of PDGFB has been implicated in several tumor types (PMID: 24359404), including oral squamous cell carcinoma (PMID: 32235327), and a fusion with COL1A1 has been reported in dermatofibrosarcoma protuberans (PMID: 31870844, PMID: 31353504). | ||||||||||
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