Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol CDK12
Synonyms CRK7 | CRKR | CRKRS
Gene Description CDK12, cyclin dependent kinase 12, is a key regulator of transcription elongation, regulates the expression of genes involved in DNA repair, and is required for the maintenance of genomic stability (PMID: 24554720; PMID: 22012619). Loss and/or inactivation of CDK12 has been commonly observed in many solid tumor types, including prostate (PMID: 29906450, PMID: 31640893), breast, ovarian, endometrial, uterine (PMID: 30104286), and is a likely tumor suppressor (PMID: 30319007).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CDK12 A1117E unknown
CDK12 A1117V unknown
CDK12 A88fs loss of function - predicted Olaparib
CDK12 amp no effect
CDK12 D502Y unknown
CDK12 D877N loss of function Olaparib
CDK12 D918N unknown
CDK12 dec exp no effect
CDK12 del loss of function Olaparib
CDK12 E1024* loss of function Olaparib
CDK12 E1171Q unknown
CDK12 E1327D unknown
CDK12 E647Kfs*8 loss of function - predicted Olaparib
CDK12 E72fs loss of function - predicted Olaparib
CDK12 E774K unknown
CDK12 E928fs loss of function Olaparib
CDK12 F89Sfs*3 loss of function - predicted Olaparib
CDK12 F986L unknown
CDK12 G1461Afs*38 unknown
CDK12 G1461C unknown
CDK12 G677D unknown
CDK12 G879V loss of function - predicted Olaparib
CDK12 G909E unknown
CDK12 G909R loss of function Olaparib
CDK12 G923V unknown
CDK12 H111fs loss of function - predicted Olaparib
CDK12 H999Y unknown
CDK12 I1131V unknown
CDK12 inact mut loss of function Olaparib
CDK12 K1422N unknown
CDK12 K208T unknown
CDK12 K211T unknown
CDK12 K46fs loss of function - predicted Olaparib
CDK12 K51R unknown
CDK12 K756R loss of function Olaparib
CDK12 K852Q unknown
CDK12 K853N unknown
CDK12 K932N unknown
CDK12 K975E loss of function Olaparib
CDK12 L122* loss of function - predicted Olaparib
CDK12 L926I no effect
CDK12 L996F loss of function Olaparib
CDK12 loss loss of function Olaparib
CDK12 mutant unknown
CDK12 P1060L unknown
CDK12 P1275L unknown
CDK12 P1325S unknown
CDK12 P250H unknown
CDK12 P335fs loss of function - predicted Olaparib
CDK12 P526H unknown
CDK12 P586S unknown
CDK12 P58fs loss of function - predicted Olaparib
CDK12 P653H unknown
CDK12 P683Qfs*70 loss of function - predicted Olaparib
CDK12 P961S unknown
CDK12 positive unknown
CDK12 Q602* loss of function - predicted Olaparib
CDK12 Q944* loss of function - predicted Olaparib
CDK12 R1008Q unknown
CDK12 R1008W unknown
CDK12 R1067* unknown
CDK12 R197L unknown
CDK12 R204fs loss of function - predicted Olaparib
CDK12 R271* loss of function - predicted Olaparib
CDK12 R378C unknown
CDK12 R722C unknown
CDK12 R779C unknown
CDK12 R779H unknown
CDK12 R858W unknown
CDK12 R882L loss of function Olaparib
CDK12 R890H unknown
CDK12 R902P unknown
CDK12 R983_E984delinsQ unknown
CDK12 S1236fs unknown
CDK12 S133Kfs*24 loss of function - predicted Olaparib
CDK12 S192Y unknown
CDK12 S343fs loss of function - predicted Olaparib
CDK12 S475Y unknown
CDK12 S587Ffs*54 loss of function - predicted Olaparib
CDK12 S62fs loss of function - predicted Olaparib
CDK12 S785fs loss of function - predicted Olaparib
CDK12 S863L unknown
CDK12 T1014_Q1016del unknown
CDK12 T212fs loss of function - predicted Olaparib
CDK12 V1055G unknown
CDK12 V39L unknown
CDK12 V919F unknown
CDK12 W1459fs unknown
CDK12 W719* loss of function Olaparib
CDK12 wild-type no effect
CDK12 Y279* loss of function - predicted Olaparib
CDK12 Y319fs loss of function - predicted Olaparib
CDK12 Y901C loss of function Olaparib
CDK12 Y968* loss of function - predicted