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Gene Symbol | CDK12 | ||||||||||
Synonyms | CRK7 | CRKR | CRKRS | ||||||||||
Gene Description | CDK12, cyclin dependent kinase 12, is a key regulator of transcription elongation, regulates the expression of genes involved in DNA repair, and is required for the maintenance of genomic stability (PMID: 24554720; PMID: 22012619). Loss and/or inactivation of CDK12 has been commonly observed in many solid tumor types, including prostate (PMID: 29906450, PMID: 31640893), breast, ovarian, endometrial, uterine (PMID: 30104286), and is a likely tumor suppressor (PMID: 30319007). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
CDK12 A1117E | unknown | |
CDK12 A1117V | unknown | |
CDK12 A88fs | loss of function - predicted | Olaparib |
CDK12 amp | no effect | |
CDK12 D502Y | unknown | |
CDK12 D877N | loss of function | Olaparib |
CDK12 D918N | unknown | |
CDK12 dec exp | no effect | |
CDK12 del | loss of function | Olaparib |
CDK12 E1024* | loss of function | Olaparib |
CDK12 E1171Q | unknown | |
CDK12 E1327D | unknown | |
CDK12 E647Kfs*8 | loss of function - predicted | Olaparib |
CDK12 E72fs | loss of function - predicted | Olaparib |
CDK12 E774K | unknown | |
CDK12 E928fs | loss of function | Olaparib |
CDK12 F89Sfs*3 | loss of function - predicted | Olaparib |
CDK12 F986L | unknown | |
CDK12 G1461Afs*38 | unknown | |
CDK12 G1461C | unknown | |
CDK12 G677D | unknown | |
CDK12 G879V | loss of function - predicted | Olaparib |
CDK12 G909E | unknown | |
CDK12 G909R | loss of function | Olaparib |
CDK12 G923V | unknown | |
CDK12 H111fs | loss of function - predicted | Olaparib |
CDK12 H999Y | unknown | |
CDK12 I1131V | unknown | |
CDK12 inact mut | loss of function | Olaparib |
CDK12 K1422N | unknown | |
CDK12 K208T | unknown | |
CDK12 K211T | unknown | |
CDK12 K46fs | loss of function - predicted | Olaparib |
CDK12 K51R | unknown | |
CDK12 K756R | loss of function | Olaparib |
CDK12 K852Q | unknown | |
CDK12 K853N | unknown | |
CDK12 K932N | unknown | |
CDK12 K975E | loss of function | Olaparib |
CDK12 L122* | loss of function - predicted | Olaparib |
CDK12 L926I | no effect | |
CDK12 L996F | loss of function | Olaparib |
CDK12 loss | loss of function | Olaparib |
CDK12 mutant | unknown | |
CDK12 P1060L | unknown | |
CDK12 P1275L | unknown | |
CDK12 P1325S | unknown | |
CDK12 P250H | unknown | |
CDK12 P335fs | loss of function - predicted | Olaparib |
CDK12 P526H | unknown | |
CDK12 P586S | unknown | |
CDK12 P58fs | loss of function - predicted | Olaparib |
CDK12 P653H | unknown | |
CDK12 P683Qfs*70 | loss of function - predicted | Olaparib |
CDK12 P961S | unknown | |
CDK12 positive | unknown | |
CDK12 Q602* | loss of function - predicted | Olaparib |
CDK12 Q944* | loss of function - predicted | Olaparib |
CDK12 R1008Q | unknown | |
CDK12 R1008W | unknown | |
CDK12 R1067* | unknown | |
CDK12 R197L | unknown | |
CDK12 R204fs | loss of function - predicted | Olaparib |
CDK12 R271* | loss of function - predicted | Olaparib |
CDK12 R378C | unknown | |
CDK12 R722C | unknown | |
CDK12 R779C | unknown | |
CDK12 R779H | unknown | |
CDK12 R858W | unknown | |
CDK12 R882L | loss of function | Olaparib |
CDK12 R890H | unknown | |
CDK12 R902P | unknown | |
CDK12 R983_E984delinsQ | unknown | |
CDK12 S1236fs | unknown | |
CDK12 S133Kfs*24 | loss of function - predicted | Olaparib |
CDK12 S192Y | unknown | |
CDK12 S343fs | loss of function - predicted | Olaparib |
CDK12 S475Y | unknown | |
CDK12 S587Ffs*54 | loss of function - predicted | Olaparib |
CDK12 S62fs | loss of function - predicted | Olaparib |
CDK12 S785fs | loss of function - predicted | Olaparib |
CDK12 S863L | unknown | |
CDK12 T1014_Q1016del | unknown | |
CDK12 T212fs | loss of function - predicted | Olaparib |
CDK12 V1055G | unknown | |
CDK12 V39L | unknown | |
CDK12 V919F | unknown | |
CDK12 W1459fs | unknown | |
CDK12 W719* | loss of function | Olaparib |
CDK12 wild-type | no effect | |
CDK12 Y279* | loss of function - predicted | Olaparib |
CDK12 Y319fs | loss of function - predicted | Olaparib |
CDK12 Y901C | loss of function | Olaparib |
CDK12 Y968* | loss of function - predicted |