Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||APLAID | FCAS3 | PLC-gamma-2 | PLC-IV|
|Gene Description||PLCG2, phospholipase C gamma 2, is a transmembrane enzyme that catalyzes the production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PMID: 31853824) and plays a role in immune-receptor signaling transduction (PMID: 27542411, PMID: 25456276, PMID: 16204312). PLCG2 mutations have been demonstrated in cutaneous T-cell lymphoma and in inhibitor-resistant chronic lymphocytic leukemia (PMID: 27542411, PMID: 25456276, PMID: 31243043).|