Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||AGOTC | PHOX1 | PMX1 | PRX-1 | PRX1|
|Gene Description||PRRX1, paired related homeobox 1, is a transcription factor that induces EMT during development and tumor invasion, and overexpression is associated with metastasis and poor prognosis in colorectal cancer (PMID: 23201163, PMID: 23807160). Downregulation of PRRX1 results in increased stemness and is associated with poor prognosis in several tumor types (PMID: 23201163, PMID: 25404478), and has been observed in salivary adenoid cystic carcinoma (PMID: 31657086) and clear cell renal cell carcinoma (PMID: 31490389).|