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Gene Symbol PRRX1
Synonyms AGOTC | PHOX1 | PMX1 | PRX-1 | PRX1
Gene Description PRRX1, paired related homeobox 1, is a transcription factor that induces EMT during development and tumor invasion, and overexpression is associated with metastasis and poor prognosis in colorectal cancer (PMID: 23201163, PMID: 23807160). Downregulation of PRRX1 also results in increased stemness, and is associated with poor prognosis in several tumor types (PMID: 23201163, PMID: 25404478).


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