Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||DCNL1 | DCUN1L1 | RP42 | SCCRO | SCRO | Tes3|
|Gene Description||DCUN1D1, defective in cullin neddylation 1 domain containing 1, encodes a component of the E3 ubiquitin ligase complex, which binds to Ubc12 and cullin, thereby resulting in increased neddylation activity and subsequent assembly of the cullin-RING ligase complexes (PMID: 18826954, PMID: 21247897). DCUN1D1 overexpression has been identified in solid tumors including squamous cell carcinoma (PMID: 15657565), prostate cancer (PMID: 29077169), and non-small cell lung carcinoma (PMID: 22500162).|