Gene Detail


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Gene Symbol DCUN1D1
Synonyms DCNL1 | DCUN1L1 | RP42 | SCCRO | SCRO | Tes3
Gene Description DCUN1D1, defective in cullin neddylation 1 domain containing 1, encodes a component of the E3 ubiquitin ligase complex, which binds to Ubc12 and cullin, thereby resulting in increased neddylation activity and subsequent assembly of the cullin-RING ligase complexes (PMID: 18826954, PMID: 21247897). DCUN1D1 overexpression has been identified in solid tumors including squamous cell carcinoma (PMID: 15657565), prostate cancer (PMID: 29077169), and non-small cell lung carcinoma (PMID: 22500162).
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