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|Gene Description||POLB, DNA polymerase beta, is the major DNA polymerase involved in DNA base excision repair (BER) and plays a role in mitochondrial function and DNA integrity (PMID: 29129598). POLB is frequently mutated in colorectal cancer (PMID: 22577134) and missense mutations have been reported in gastric cancer (PMID: 25561897).|