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Gene Symbol POLD1
Synonyms CDC2 | CRCS10 | MDPL | POLD
Gene Description POLD1, DNA polymerase delta 1, catalytic subunit, is the catalytic subunit and the largest of four subunits that form the DNA polymerase delta holoenzyme, which mediates DNA replication (PMID: 27320729) and repair (PMID: 30625304). Germline and somatic mutations in POLD1 have been identified in a variety of human cancers (PMID: 27320729), including colorectal cancer (PMID: 31769227) and lung cancer (PMID: 31673068), and may be associated with high tumor mutational burden and response to immunotherapy (PMID: 31741177, PMID: 31673068, PMID: 31415061, PMID: 30524909).
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