Gene Detail

Gene Symbol POLE
Synonyms CRCS12 | FILS | POLE1
Gene Description POLE, polymerase (DNA directed), epsilon, catalytic subunit, is the catalytic subunit of DNA polymerase epsilon, which mediates DNA repair and replication (PMID: 26822575). POLE mutations are frequently identified in cancers, particularly in colorectal and endometrial cancers (PMID: 26822575).
Entrez Id 5426
Chromosome 12
Map Location 12q24.33
Canonical Transcript NM_006231

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