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|Synonyms||hRPB220 | hsRPB1 | NEDHIB | POLR2 | POLRA | RPB1 | RPBh1 | RpIILS | RPO2 | RPOL2|
|Gene Description||POLR2A, polymerase (RNA) II subunit A, encodes for the largest RNA polymerase II subunit, which is responsible for the transcription of RNA and thus, required for cell survival (PMID: 8990153). POLR2A variants have been identified in several types of cancer including menigiomas (PMID: 27548314) and colorectal cancer, where POLR2A loss is often linked to hemizygous loss of TP53 (PMID: 25985938).|