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Gene Symbol POLR2A
Synonyms hRPB220 | hsRPB1 | NEDHIB | POLR2 | POLRA | RPB1 | RPBh1 | RpIILS | RPO2 | RPOL2
Gene Description POLR2A, RNA polymerase II subunit A, encodes for the largest RNA polymerase II subunit, which is responsible for the transcription of RNA and thus, required for cell survival (PMID: 8990153). POLR2A mutations have been identified in several types of cancer including menigiomas (PMID: 27548314) and colorectal cancer, where POLR2A loss is often linked to hemizygous loss of TP53 (PMID: 25985938).


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