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Gene Symbol UGT1A1
Synonyms BILIQTL1 | GNT1 | HUG-BR1 | UDPGT | UDPGT 1-1 | UGT1 | UGT1A
Gene Description UGT1A1, UDP-glucuronosyltransferase 1-1, is an enzyme that catalyzes the glucuronidation of substances to soluble metabolites for excretion (PMID: 28520360). Genetic polymorphisms in UGT1A1 may alter the metabolism of chemotherapy drugs such as irinotecan, resulting in severe toxicity (PMID: 28494109, PMID: 28502040, PMID: 28585035, PMID: 30645764).
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