Gene Detail

Gene Symbol RNF43
Synonyms RNF124 | SSPCS | URCC
Gene Description RNF43, ring finger protein 43, is an E3 ubiquitin ligase that targets Frizzled receptors, resulting in lysosomal degradation of Frizzleds and negative regulation of Wnt signaling (PMID: 25460271). RNF43 mutations are associated with several tumor types, and are frequent in colorectal and endometrial cancer (PMID: 25460271, PMID: 25344691).
Entrez Id 54894
Chromosome 17
Map Location 17q22
Canonical Transcript NM_017763


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