Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol LAMTOR1
Synonyms C11orf59 | p18 | p27RF-Rho | PDRO | Ragulator1
Gene Description LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, acts as the anchor protein for a complex that functions to tether mTORC1 to lysosomes, which plays a role in activation of mTORC1 and in T-cell function (PMID: 29158492, PMID: 28768723, PMID: 24377928). A LAMTOR1-AKT1 fusion has been identified in an indeterminate epithelioid neoplasm (PMID: 30877085), and a fusion with PRKCD has been identified in benign fibrous histiocytoma (PMID: 24721208, PMID: 26432191).
Additional content available in CKB BOOST