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|Synonyms||C11orf59 | p18 | p27RF-Rho | PDRO | Ragulator1|
|Gene Description||LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, acts as the anchor protein for a complex that functions to tether mTORC1 to lysosomes, which plays a role in activation of mTORC1 and in T-cell function (PMID: 29158492, PMID: 28768723, PMID: 24377928). A fusion between LAMTOR1 and AKT1 has been identified in an indeterminate epithelioid neoplasm (PMID: 30877085), and a fusion with PRKCD has been identified in benign fibrous histocytoma (PMID: 24721208, PMID: 26432191).|