Gene Detail
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| Gene Symbol | CHD7 | ||||||||||
| Synonyms | CRG | HH5 | IS3 | KAL5 | ||||||||||
| Gene Description | CHD7, chromodomain helicase DNA binding protein 7, encodes an ATP-dependent chromatin remodeling enzyme that plays a role in regulating gene expression in embryonic stem cells during development (PMID: 20657823), neural crest formation (PMID: 20130577), neural progenitors in the central nervous system (PMID: 30108144, PMID: 29440260, PMID: 26928066), and ribosomal RNA biogenesis (PMID: 20591827). Increased CHD7 expression has been observed in glioma (PMID: 30850678) and breast cancer (PMID: 28649742), and a fusion with BEND2 has been identified in a pancreatic neuroendocrine tumor (PMID: 31160355). | ||||||||||
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