Gene Detail


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Gene Symbol FRMD4A
Synonyms bA295P9.4 | CCAFCA | FRMD4
Gene Description FRMD4A, FERM domain containing 4A, encodes a scaffold protein which links Arf6 with the Par protein complex and is involved in regulating cell polarity, cytoskeletal and membrane organization, and protein secretion (PMID: 20080746, PMID: 25388005, PMID: 27044754). Overexpression of FRMD4A has been observed in squamous cell carcinomas (PMID: 22564525, PMID: 27666346) and rectal cancer (PMID: 26893625), and a fusion of FRMD4A with RET has been identified in non-small cell lung cancer (PMID: 28115111).
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